Papers

Regulation of neuronal bioenergetics as a therapeutic strategy in neurodegenerative diseases

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RNA Sequencing of Neurodegenerative Disease Postmortem CNS Tissues from Persons with Amyotrophic Lateral Sclerosis, or Alzheimer’s or Parkinson’s Diseases Reveal Heterogeneous Dysregulation of Gene Expression

James P. Bennett, Jr. M.D1,2., Ph.D., Paula M. Keeney1,2, B.S., David G. Brohawn2,3*, Ph.D. 1Neurodegeneration Therapeutics, Inc. 3050A Berkmar Drive, ...
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Increased Oxidative Stress and NLRP3 Inflammasome Activation May Drive “Cytokine Storms” in Aging, Type 2 Diabetes, Cardiovascular Disease, Obesity and Hypertension in Persons with SARS-CoV-2 Infections

James P. Bennett, Jr. Neurodegeneration Therapeutics, Inc. Charlottesville, VA 22901 Correspondence: James P. Bennett, Jr. M.D. Ph.D. Neurodegeneration Therapeutics, Inc ...
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Alzheimer’s and Parkinson’s Brain Tissues Have Reduced Expression of Genes for mtDNA OXPHOS Proteins, Mitobiogenesis Regulator PGC-1α Protein and mtRNA Stabilizing Protein LRPPRC (LRP130)

James P. Bennett, Jr. M.D., Ph.D.1 and Paula M. Keeney, B.S.11Neurodegeneration Therapeutics, Inc.Charlottesville, VA 22901Correspondence:James P. Bennett, Jr. M.D., Ph.D.Neurodegeneration ...
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SARS-CoV-2 Genome Contains Mature miRNA Sequences That Can Interact Strongly With Human mRNA Genes

Running Title: SARS-CoV-2 miRNA’s and Human Genes James P. Bennett, Jr. Neurodegeneration Therapeutics, Inc. Charlottesville, Virginia Send Correspondence To: James ...
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Human Microglia in Culture as a Model for Brain Neuro-inflammation

 June 18, 2019 Introduction: Activation of brain immune cells (microglia) leads to the secretion by those activated microglia of chemicals ...
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Development of a Human Neural Cell Model for Developmental Neurotoxins

June 17. 2019 Introduction: Developmental neurotoxins (DNtxn) are man-made chemicals in our environment, typically used as insecticides/agricultural chemicals, which impair ...
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RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues from Amyotrophic Lateral Sclerosis, Alzheimer’s Disease and Parkinson’s Disease Subjects and Increased Expression of Genes from Disease-Activated Microglia.

James P. Bennett, Jr.(1, 2), Paula M. Keeney (1, 2) and David G. Brohawn (2, 3)*1 Neurodegeneration Therapeutics, Inc., Charlottesville, ...
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Alzheimer’s Disease Frontal Cortex Mitochondria Show a Loss of Individual Respiratory Proteins But Preservation of Respiratory Supercomplexes

 Paula M. Kenney and James P. Bennett, Jr. Neurodegeneration Therapeutics, Inc. Charlottesville, VA Correspondence: James P. Bennett, Jr. M.D.,Ph.D. Neurodegeneration ...
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RNA Sequencing Reveals Small and Variable Contributions of Infectious Agents to Transcriptomes of Postmortem Nervous Tissues from Amyotrophic Lateral Sclerosis, Alzheimer’s Disease and Parkinson’s Disease Subjects and Increased Expression of Genes from Disease-Activated Microglia

James P. Bennett, Jr.1, 2, Paula M. Keeney1,2 and David G. Brohawn2, 3* 1 Neurodegeneration Therapeutics, Inc., Charlottesville, VA 2 ...
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